The greatest battle lies within.
The seemingly invincible Spider-Man goes up against an all-new crop of villains—including the shape-shifting Sandman. While Spider-Man’s superpowers are altered by an alien organism, his alter ego, Peter Parker, deals with nemesis Eddie Brock and also gets caught up in a love triangle.
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Tobey MaguireSpider-Man / Peter Parker
Kirsten DunstMary Jane Watson
James FrancoNew Goblin / Harry Osborn
Thomas Haden ChurchSandman / Flint Marko
Topher GraceVenom / Eddie Brock
Bryce Dallas HowardGwen Stacy
Rosemary HarrisMay Parker
J.K. SimmonsJ. Jonah Jameson
James CromwellCaptain Stacy
Dylan BakerDr. Curt Connors
Theresa RussellEmma Marko
Bill NunnJoseph 'Robbie' Robertson
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